I-genome volution, pangenome
Yini i-pan-genome?
Ubufakazi obunqwabelene bukhombisa ukuthi ukuhlukahluka phakathi kwezinhlobo ezahlukene zezinhlobo kungaba nkulu. I-genome eyodwa eyodwa kude nokwanele ukuthola isithombe sonke semininingwane yofuzo lwezinhlobo ezizodwa. Inhloso ye-Pan-Genome Study ukuthola igrafu ephelele ye-genomic yezinhlobo zezilwane bese unquma ubudlelwano phakathi kwezimpawu namakhodi wezakhi zofuzo ngokwenza i-genome de Novo Novo ye-Novon of inqwaba yezinhlobo eziningi, ezivumela ukuhlukahluka okujulile nokubanzi kokuhlukahluka.
Izitayela Zocwaningo lwePan-Genome
Umdwebo 1 Izitayela zamaphepha okucwaninga ashicilelwe ePan-Genome.
Qaphela: Isibalo sibonisa umphumela wokuthatha "i-pan-genome" njengegama eliyisihluthulelo ukusesha izihloko zezihloko ezishicilelwe ngemvelo, amaseli kanye nesayensi clouk
a. Kufundwa kusuka kumasampula amaningi ahambisana nesethenjwa nakubo abangabekezelelwanga bahlangene bangene emihlanganweni yenoveli. Ngokungeza lokhu kuhlangana kwenoveli kokulandelana kokubhekelwa kwereferensi yasekuqaleni, kungakhiwa ireferensi ye-pangenome. Izifunda ezingakabizi zinqunywa ngokususelwa kumephu konke kufundela emuva ku-pangenome.
b. Umhlangano we-DE Novo worlomes wezinto eziningi uvumela izindlela zonke zohlobo lokuhlonza ukukhomba izifunda ezabekayo ze-genomic.
c. Igrafu ye-Pan-Genome ingakhiwa kusuka ekuvumelaneni yonke kwe-genome noma umhlangano wegrafu, okugcina kahle imininingwane ehlukile yezifunda ezisetshenzisiwe njengezindlela ezihlukile ngegrafu.
Ungazakha kanjani i-pan-genome?
Umdwebo 2 Ukuqhathanisa Izindlela zePan-Genome1
a. Kufundwa kusuka kumasampula amaningi ahambisana nesethenjwa nakubo abangabekezelelwanga bahlangene bangene emihlanganweni yenoveli. Ngokungeza lokhu kuhlangana kwenoveli kokulandelana kokubhekelwa kwereferensi yasekuqaleni, kungakhiwa ireferensi ye-pangenome. Izifunda ezingakabizi zinqunywa ngokususelwa kumephu konke kufundela emuva ku-pangenome.
b. Umhlangano we-DE Novo worlomes wezinto eziningi uvumela izindlela zonke zohlobo lokuhlonza ukukhomba izifunda ezabekayo ze-genomic.
c. Igrafu ye-Pan-Genome ingakhiwa kusuka ekuvumelaneni yonke kwe-genome noma umhlangano wegrafu, okugcina kahle imininingwane ehlukile yezifunda ezisetshenzisiwe njengezindlela ezihlukile ngegrafu.
Muva nje eshicilelwe pan-genomes
● Pan Pan-genomes2
● I-Tomato Pan-shomes 3
● I-PAN nePAN -GENEME4
● I-sunflower pan-genomeOkuthengwa edolo
● I-soybean pan-genome 6
● I-PAN-PEN-GenmeOkuthengwa kwava +
● IBarley Pan-Genme8
● I-Wheat Pan-Genome9
● I-sorghum pan-genomeOkuthenyalwayo
● Phytoplankton pan-genomeUhlamvu lweshumi eliphansi
Inkomba
1. Bayer PE, Golicz AA, Scheben a, Batley J, Edward D. Plast Pan Pan-Genemes yireferensi entsha. Izitshalo ze-NAT. 2020; 6 (8): 914-920. Doi: 10.1038 / S41477-020-0733-0
2. Iculo JM, Guan z, Hu J, et al. I-genomes eyisishiyagalombili esezingeni eliphakeme iveza ukwakhiwa kwe-pan-genome nokwahlukaniswa kwe-ecotype ye-Brassica napus. Izitshalo ze-NAT. 2020; 6 (1): 34-45. doi: 10.1038 / S414-0577-7
3. UGao l, Gonda i, ilanga h, et al. I-Tomato Pan-Genome yenza izakhi zofuzo ezintsha kanye nokunambitheka okungavamile okulawula izithelo. I-NAT get. Ngo-2019; 51 (6): 1044-1051. doi: 10.1038 / s41588-019-0410-2
4. Zhao Q, Feng Q, Lu H, et al. Ukuhlaziywa kwe-Pan-Genome kugcizelela ubukhulu bokuhlukahluka kwe-genomic ku-limed etshaliwe nelayisi sasendle [ukulungiswa okushicilelwe kuvela geet get. Ngo-2018 Aug; 50 (8): 1196]. I-NAT get. 2018; 50 (2): 278-284. doi: 10.1038 / S41588-018-0041-Z
5. IHübner S, Bercovich n, Todesco M, et al. Ukuhlaziywa kwe-sunflower Pan-Genome kukhombisa ukuthi i-hybridizatization eguqulwe okuqukethwe kohlobo nokungalingani kwezifo. Izitshalo ze-NAT. Ngo-2019; 5 (1): 54-62. DOI: 10.1038 / S41477-018-0329-0
6. I-LIU Y, DU H, LI P, et al. I-PAN-Genome of Wild and Jumedical Soybeans. Iseli. 2020; 182 (1): 162-176.e13. doi: 10.1016 / J.Cell.2020.05.023
7. Qin P, lu h, du h, et al. Ukuhlaziywa kwe-Pan-Genome kwezingu-33 zofuzo ezahlukahlukene zelayisi ezihlukile kwembula ukuhlukahluka okufihliwe genomic [kushicilelwe online ngaphambi kokuphrinta, 2021 Meyi 25]. Iseli. 2021; S0092-8674 (21) 00581-X. doi: 10.1016 / J.Cell.2021.04.046
8. UJayakodi M, Padmarasu S, Haberser G, et al. I-Barley Pan-Genome yembula ifa elifihlekile lokufuya kwezakhi zofuzo. Imvelo. 2020; 588 (7837): 284-289. doi: 10.1038 / S41586-020-2947-8
9. I-Wallowiak S, GAO L, Monat C, et al. Ama-gethomes amaningi wokobhomu aveza ukuhluka komhlaba ngokuzalela kwanamuhla. Imvelo. 2020; 588 (7837): 277-283. doi: 10.1038 / S41586-020-2961-X
10. Tao Y, Luo H, Xu J, et al. Ukwehluka okuningana ngaphakathi kwePan-Genome of Crimedical and Wild Sorghum [eshicilelwe online ngaphambi kokuphrinta, 2021 Meyi 20]. Izitshalo ze-NAT. 2021; 10.1038 / S41477-021-00925-X. doi: 10.1038 / s41477-021-00925-X
11. Fan X, Qiu h, han w, et al. I-Phytoplankton Pangenome iveza ukudluliselwa kweGenePe ISCI Adv. I-2020; 6 (18): I-EABA0111. Ishicilelwe ngo-2020 APR 29. Doi: 10.11126 / SCIADV.Aba0111
Isikhathi sePosi: Jan-04-2022