Izindaba ezijabulisayo! I-BMKGENE ithuthukise uchungechunge lwe-BMKMANU S lwe-spatial transcriptomics chip enobuchwepheshe bokuhlukaniswa kwamaseli isizwa ukuhlaziya okunembayo kwephethini ye-cral evolution ye-acral melanoma yiqembu lika-Li Hang, u-Zhang Ning, no-Xue Ruidong base-Peking University, ucwaningo lushicilelwe ku- Iseli Lomdlavuza (IF=50.3).
Ucwaningo, olusekelwe ekulandeleni kwama-multi-omics okuhlanganisa i-whole-exome, i-microdissected multi-regional whole-exome, i-bulk transcriptome, i-single-cell transcriptome, i-spatial transcriptome, kanye ne-CODEX proteomics yendawo, yembula ngokuhlelekile iphethini yokuvela kwe-clonal ye-acral melanoma futhi yasungulwa. ama-subtypes awo ama-molecule. Ngokusebenzisa ubuchwepheshe bokuhlukaniswa kwamaseli e-BMKMANU S1000, iziguli eziyi-10 ze-acral melanoma zahlolwa, zaqinisekisa ukusebenzisana okuqondile kwendawo phakathi kwama-APOE+/CD163+ TAM namaseli e-EMT tumor. Ngaphezu kwalokho, izimpawu ezintsha zokuxilonga zangaphambi kwesikhathi (ukuguqulwa komshayeli nokubandakanyeka kwe-appendage) kanye nezimpawu zokubikezela sekwephuzile (i-APOE ne-CD163) zihlonzwe futhi zaqinisekiswa, zinikeza ulwazi olubalulekile lokuxilonga kusenesikhathi kanye nokwelashwa okunembayo kwe-acral melanoma.
Uma ungathanda ukufunda okwengeziwe ngalolu cwaningo, finyelelalesi sixhumanisi.Ukuze uthole ulwazi olwengeziwe mayelana nezinsizakalo zethu zokulandelanisa kanye ne-bioinformatics, ungakhuluma nathi lapha.
Isikhathi sokuthumela: Jul-17-2024