Awọn iroyin igbadun! BMKGENE ni idagbasoke BMKMANU S jara awọn transcriptomics aye-aye pẹlu imọ-ẹrọ ipin sẹẹli ti o ṣe iranlọwọ nipasẹ itupalẹ pipe-giga ti ilana itankalẹ clonal ti acral melanoma nipasẹ ẹgbẹ Li Hang, Zhang Ning, ati Xue Ruidong lati Ile-ẹkọ giga Peking, iwadi naa ti tẹjade ni Ẹjẹ akàn (IF = 50.3).
Iwadi na, ti o da lori ipasẹ olona-omics pẹlu gbogbo-exome, microdissected olona-agbegbe gbogbo-exome, olopobobo transcriptome, ẹyọkan sẹẹli transcriptome, aye transcriptome, ati CODEX spatial proteomics, ifinufindo han awọn clonal ilana itankalẹ clonal ti tete acral melanoma ati ti iṣeto. molikula subtypes. Nipa lilo BMKMANU S1000 spatial transcriptome cell segmentation technology, 10 acral melanoma alaisan ti wa ni ayewo, ifẹsẹmulẹ awọn ibaraẹnisọrọ aaye taara laarin APOE +/CD163+ TAMs ati awọn sẹẹli tumo EMT. Pẹlupẹlu, awọn asami iwadii kutukutu tuntun (awọn iyipada awakọ ati ilowosi ohun elo) ati awọn asami asọtẹlẹ pẹ (APOE ati CD163) ni a ṣe idanimọ ati ifọwọsi, pese alaye pataki fun iwadii kutukutu ati itọju pipe ti melanoma acral.
Ti o ba fẹ lati ni imọ siwaju sii nipa iwadi yii, wọle siyi ọna asopọ.Fun alaye diẹ sii lori ilana atẹle wa ati awọn iṣẹ bioinformatics, o le ba wa sọrọ nibi.
Akoko ifiweranṣẹ: Oṣu Keje-17-2024