I-Genome ivelution, ipangenome
Yintoni i-pan-genome?
Amangqina aqokelelweyo abonisa ukuba umahluko phakathi kwezinto ezahlukeneyo zohlobo lunokuba lukhulu. I-genome enye enye ikwaneleyo ukuze ufumane wonke umfanekiso wolwazi lwendalo lweentlobo enye. Injongo ye-pan-genome yesifundo sokufumana igrafu ebanzi ngakumbi yohlobo kwaye ihlole ubudlelwane phakathi kweempawu kunye neekhowudi zemfuza ngokuqhuba indibano ye-genome de novo ye-genom, evumela ukumbiwa kwezahluko ezininzi.
Iindlela zophando lwe-pan-genome
Umzobo 1 Imikhwa yamaphepha ophando epapashiweyo yePan-Genome.
Qaphela: Umfanekiso ubonakalisa isiphumo sokuthatha "i-pan-genome" njengegama eliphambili ukukhangela izihloko zamanqaku apapashwe kwindalo, iselfowuni kunye neNzululwazi yeNjongo
a. Ifunda kwiisampulu ezininzi zihambelana nesalathiso kwaye ezingafakwanga zidibene kwi-noveves ntokheli. Ngokongeza la manqaku kwi-noveves kulandelelwano lwesalathiso, isalathiso sePangenome sinokwakhiwa. Imimandla enika indawo yokunika igqitywe isekwe kwimephu yonke ifundwayo kwi-pangenome.
b. Indibano ye-De Novo ye-genomes yezixhobo ezininzi zokuphunyezwa ivumela iindlela zokulungelelanisa i-genome iphela ukuze kuchongwe imimandla ye-geminic esulelekileyo.
c. Igrafu ye-pan-genome inokwakhiwa kwi-genome yonke okanye yiNdibano yeGe Nowel yeGenovo, egcina ulwazi olusebenzayo lwemimandla esebenzayo njengeendlela ezizodwa kwigrafu.
Unokwakha njani i-pan-genome?
Umzobo 2 uthelekiso lweendlela ze-pan-genome1
a. Ifunda kwiisampulu ezininzi zihambelana nesalathiso kwaye ezingafakwanga zidibene kwi-noveves ntokheli. Ngokongeza la manqaku kwi-noveves kulandelelwano lwesalathiso, isalathiso sePangenome sinokwakhiwa. Imimandla enika indawo yokunika igqitywe isekwe kwimephu yonke ifundwayo kwi-pangenome.
b. Indibano ye-De Novo ye-genomes yezixhobo ezininzi zokuphunyezwa ivumela iindlela zokulungelelanisa i-genome iphela ukuze kuchongwe imimandla ye-geminic esulelekileyo.
c. Igrafu ye-pan-genome inokwakhiwa kwi-genome yonke okanye yiNdibano yeGe Nowel yeGenovo, egcina ulwazi olusebenzayo lwemimandla esebenzayo njengeendlela ezizodwa kwigrafu.
Kupapashwa kutshanje kwi-pan-genomes
● I-gen-genomes2
● I-Tomato Pan-Genemes 3
● I-pan -genome4
● I-Sunflower pan-genome5
● I-soybean pan-genome 6
● I-ran-genome7
● I-pan-genome8
● I-Pan-Ge-Ge-InOme9
● I-Sorghum Pan-Genome10
● I-phytoplankton pan-genome11
Ireferensi
I-1. U-Bayer Pe, uGoliliz A, Scheben A, Blibeley J, E-Edward D. Izityalo zePan-Revimes yireferensi entsha. I-Nat National. 2020; 6 (8): 914-920. Doi: 10.1038 / S41477-020-0733-0-0-0
2. Ingoma Jm, Guan Z, Hu J, et al. I-genomes ezisibhozo ezikumgangatho ophezulu-mbini zibonisa uyilo lwe-pan-genome nolwahlulo kunye nolwahlulo lwe-ecotype ye-brassica napis. I-Nat National. 2020; 6 (1): 34-45. I-DoI: 10.1038 / S41477-019-0577-7-7-7
3. Gao L, Gonda i, langa hanga h, et al. I-Tomato Pan-Genome ifaka imfuza entsha kunye ne-allele enqabileyo elawula incasa yeziqhamo. Nat Geet. 2019; 51 (6): 1044-1051. Doi: 10.1038 / S41588-019-0410-2
4. UZhao Q, feng q, lu h, et al. Uhlalutyo lwe-pan-genome lubonisa ubungakanani botshintsho lwe-gemic kwilinywe kunye nerayisi yasendle [Ukulungiswa okupapashiweyo kuvela kwi-Nat Genet. Ngo-2018 Aug; 50 (8): 1196]. Nat Geet. 2018; 50 (2): 278-284. Doi: 10.1038 / S41588-018-0041-Z
5. UHübner S, Bercovich n, Todsco m, et al. Uhlalutyo lwejoni-genome lubonisa ukuba i-hybridization itshintshwa kunye nokuxhathisa izifo. I-Nat National. 2019; 5 (1): 54-62. Doi: 10.1038 / S41477-018-0329-0-0-0-0
6. Liu y, du h, li p, et al. I-pan-genome yasendle kwaye ityale imbotyi yesoya. Iseli. 2020; 182 (1): 162-176.e13. Doi: 10.1016 / J.CEll.2020.05.023
7. UQin P, LU H, du H, et al. Uhlalutyo lwe-pan-genono lwe-33 yelayisi eyahlukileyo ebonisa ukuba izinto ezifihliweyo ze-genomic zityhila umahluko ofihlakeleyo we-genomic [epapashiweyo kwi-Intanethi ngaphambi kokuprinta, ezingama-2021 kaMeyi] 25]. Iseli. 2021; s0092-8674 (21) 00581-x. DoI: 10.1016 / J.CEll.2021.04.046
8. UJayakodo M, Padmarasus, Haberer g, et al. I-Pariloy Pan-Genome ityhila ilifa elifihlakeleyo lokuzala. Indalo. 2020; 588 (7837): 284-289. I-DoI: 10.1038 / S41586-020-2947-8
9. I-Walkiak s, Gao L, Monat C, et al. I-genomes ezininzi zengqolowa zibonisa umahluko wehlabathi kuphumelo lwehlabathi. Indalo. 2020; 588 (7837): 277-283. Doi: 10.1038 / S41586-020-2961-X
10. Tao y, Luo h, Xu J, et al. Umahluko obanzi kwi-pan-genome ye-sorghum yelinywe kunye ne-sorghum yasendle ngaphambi kokuprinta, 2021 kaMeyi 20]. I-Nat National. 2021; 10.1038 / S41477-021-00925-X. I-DoI: 10.1038 / S41477-021-00925-X
11. Fan X, Qiu h, Han W, et al. I-phytoplankton pangelenome ibonisa ukudluliselwa kwe-prokaryotic the the the the Gene I-SCID. 2020; 6 (18): E-Eaba0111. Ipapashwe 2020 APR 29. Doi: 10.1126 / Scidv.ba0111
IXESHA LOKUQALA: UJan-04 ukuya ku-522