I-DNA methylation yenye yezona zinto zifundwa kakhulu ngokuguqulwa kwe-epigenetic. Idlala indima ebalulekileyo kuzinzo lwe-genome, ukulawulwa koshicilelo lwemfuza, kunye nophuhliso lweempawu. Ukubhalwa kofuzo kuchongwa yimeko yabo ye-methylation, kunye namanqanaba aphantsi e-methylation ahambelana nokubonakaliswa kofuzo kunye namanqanaba aphezulu e-methylation ahambelana nokuthuliswa kofuzo.
Ukudibanisa i-whole-genome bisulfite sequencing (WGBS) kunye nedatha ye-RNA-seq ivumela uhlalutyo olubanzi lwe-genome kunye ne-transcriptome, ukutyhila iindlela zokulawula i-gene, kunye nokuchonga iindlela ze-biological ze-novel kunye ne-biomarkers. Unxulumano phakathi kwe-transcriptome kunye ne-methylation sequencing data inokusekwa ngokusekelwe kwijene, ukudibanisa zombini i-datasets usebenzisa i-genes njengebhuloho.
Olu hlalutyo lunceda ukuqonda ulungelelwaniso phakathi kwe-DNA methylation kunye ne-gene expression, ukuchonga izakhi zofuzo eziphenjelelwa yi-methylation, kunye nokuphanda iziphumo zokusebenza ezisezantsi.
Zive ukhululekile ukuqhagamshelana ne-BMKGENE ngolwazi olungenakulinganiswa kuphando lwe-epigenetic.
Ixesha lokuposa: Dec-05-2023