Iindaba ezimnandi! I-BMKGENE iphuhlise i-BMKMANU S ye-chip ye-spatial transcriptomics chip kunye netekhnoloji yokwahlulahlula iiseli incediswa lucazululo oluchanekileyo lwepateni ye-cral evolution ye-acral melanoma liqela lika-Li Hang, uZhang Ning, kunye no-Xue Ruidong ovela kwiYunivesithi yasePeking, uphando luye lwapapashwa Iseli yoMhlaza (IF=50.3).
Uphononongo, olusekwe kulandelelwano lwee-omics ezininzi kubandakanya i-exome epheleleyo, i-microdissected multi-regional whole-exome, i-bulk transcriptome, i-cell-cell transcriptome, i-spatial transcriptome, kunye ne-CODEX proteomics yendawo, ityhile ngokucwangcisiweyo ipateni ye-clonal ye-acral melanoma kwaye yasekwa. ii-subtypes zayo zemolekyuli. Ngokusebenzisa iteknoloji ye-BMKMANU S1000 ye-spatial transcriptome segmentation cell, izigulane ze-acral melanoma zavavanywa, ziqinisekisa ukusebenzisana okuthe ngqo kwendawo phakathi kwe-APOE +/CD163+ TAM kunye neeseli ze-tumor ze-EMT. Ngaphaya koko, iziphawuli ezintsha zokuxilonga kwangethuba (utshintsho kumqhubi kunye nokubandakanyeka kwe-appendage) kunye neempawu zeprognosis kade (APOE kunye ne-CD163) zichongiwe kwaye zaqinisekiswa, zibonelela ngolwazi olubalulekileyo lokuxilongwa kwangoko kunye nonyango oluchanekileyo lwe-acral melanoma.
Ukuba ungathanda ukufunda ngakumbi ngolu phononongo, fikelelaelikhonkco.Ngolwazi oluthe kratya malunga nolandelelwano kunye neenkonzo ze-bioinformatics, ungathetha nathi apha.
Ixesha lokuposa: Jul-17-2024