Tala fiafia! BMKGENE atiina ae le BMKMANU S faasologa spatial transcriptomic chip ma le tekinolosi vaega vaega fesoasoani e le maualuga-saʻo auʻiliʻiliga o le clonal evolution mamanu o acral melanoma e le au a Li Hang, Zhang Ning, ma Xue Ruidong mai le Iunivesite o Peking, o le suesuega ua lomia faasalalau i totonu. Cell Kanesa (IF=50.3).
O le suʻesuʻega, e faʻavae i luga o le tele-omics sequencing e aofia ai le whole-exome, microdissected multi-regional whole-exome, bulk transcriptome, single-cell transcriptome, spatial transcriptome, ma CODEX spatial proteomics, faʻaalia faʻasolosolo le clonal evolution pattern of early acral melanoma ma faavaeina. ona subtype mole. I le faʻaaogaina o le BMKMANU S1000 spatial transcriptome cell segmentation technology, 10 acral melanoma maʻi na suʻesuʻeina, faʻamaonia fesoʻotaʻiga tuusaʻo i le va o APOE + / CD163 + TAMs ma EMT sela tumo. E le gata i lea, o faʻailoga fou o suʻesuʻega (suiga o avetaʻavale ma faʻapipiʻi faʻapipiʻi) ma faʻailoga tuai (APOE ma le CD163) na faʻamaonia ma faʻamaonia, tuʻuina atu faʻamatalaga taua mo suʻesuʻega vave ma togafitiga saʻo o le acral melanoma.
Afai e te fia iloa atili e uiga i lenei suʻesuʻega, avanoalenei sootaga.Mo nisi faʻamatalaga i la matou faʻasologa ma bioinformatics auaunaga, e mafai ona e talanoa mai ia i matou iinei.
Taimi meli: Iul-17-2024