BMKGENE inapereka zambiri zotsatizana ndi RNA zotsatizana ndi ntchito za kafukufukuyu: Mabala olowera adipocyte si myofibroblasts.
Nkhaniyi idasindikizidwa mu Nature Communications, imayang'ana momwe mapulasitiki angapangidwe a adipocytes ndi ma fibroblasts atavulala pakhungu. Pogwiritsa ntchito kutsata mizere ya chibadwa ndi kuyerekeza kwamoyo muzowonjezera ndi nyama zovulala, onani kuti kuvulala kumapangitsa kusamuka kwanthawi yayitali mu adipocytes omwe ali ndi machitidwe osiyana siyana amasamuka ndi machitidwe kuchokera ku fibroblasts.
Kuphatikiza apo, ma adipocyte osamukasamuka, samathandizira kupangika kwa zipsera ndipo amakhalabe opanda fibrogenic mu m'galasi, mu vivo, komanso pakuwaika m'mabala anyama. Mwachidule, ma adipocytes ovulala omwe amasamukira kumayiko ena amakhalabe oletsa mzere ndipo samasinthasintha kapena kukonzanso kukhala fibrosing phenotype. Zomwe zapezazi zimakhudza kwambiri njira zoyambira komanso zomasulira m'munda wamankhwala obwezeretsanso, kuphatikiza chithandizo chachipatala chokonza mabala, matenda a shuga, ndi fibrotic pathologies.
Dinani apa kutiphunzirani zambiri za phunziroli
Nthawi yotumiza: Aug-29-2023