Akụkọ na-atọ ụtọ! BMKGENE mepụtara BMKMANU S usoro spatial transcriptomics chip na teknụzụ nkebi cell na-enyere aka site na nyocha dị elu nke usoro evolushọn nke acral melanoma nke ndị otu Li Hang, Zhang Ning na Xue Ruidong sitere na Mahadum Peking, ebipụtala nyocha ahụ na Cell Cancer (IF = 50.3).
Ọmụmụ ihe ahụ, dabere na usoro nke multi-omics gụnyere exome dum, microdissected multi-regional whole-exome, transcriptome buru ibu, transcriptome otu cell, transcriptome spatial, na CODEX spatial proteomics, kpughere n'usoro usoro evolushọn nke clonal nke melanoma n'oge mbụ wee guzobe ya. ya molekụla subtypes. Site na iji BMKMANU S1000 spatial transcriptome cell segmentation technology, a na-enyocha ndị ọrịa 10 acral melanoma, na-akwado mmekọrịta dị n'etiti APOE +/ CD163+ TAMs na EMT tumor cell. Ọzọkwa, achọpụtara ihe nrịbama mmalite mmalite (mgbanwe ndị ọkwọ ụgbọ ala na ntinye aka) na akara nrịbama mbubreyo (APOE na CD163) ma kwado ya, na-enye ozi dị mkpa maka nchọpụta mmalite na ọgwụgwọ ziri ezi nke acral melanoma.
Ọ bụrụ na ị ga-achọ ịmụtakwu maka ọmụmụ ihe a, nwetanjikọ a.Maka ozi ndị ọzọ gbasara usoro anyị na ọrụ bioinformatics, ị nwere ike ịgwa anyị okwu ebe a.
Oge nzipu: Jul-17-2024