Tshaj tawm tshwj xeeb

Xov xwm zoo siab heev! BMKGENE tsim BMKMANU S series spatial transcriptomics nti nrog cov xov tooj ntawm tes segmentation thev naus laus zis pab los ntawm kev soj ntsuam siab ntawm clonal evolution qauv ntawm acral melanoma los ntawm pab pawg ntawm Li Hang, Zhang Ning, thiab Xue Ruidong los ntawm Peking University, kev tshawb fawb tau luam tawm hauv Cancer Cell (IF = 50.3).

Txoj kev tshawb no, raws li multi-omics sequencing nrog rau tag nrho-exome, microdissected multi-regional tag nrho-exome, bulk transcriptome, ib leeg-cell transcriptome, spatial transcriptome, thiab CODEX spatial proteomics, systematically qhia lub clonal evolution qauv ntawm thaum ntxov acral melanoma thiab tsim. nws molecular subtypes. Los ntawm kev siv BMKMANU S1000 spatial transcriptome cell segmentation thev naus laus zis, 10 tus neeg mob acral melanoma tau kuaj xyuas, lees paub qhov sib cuam tshuam ncaj qha ntawm APOE + / CD163+ TAMs thiab EMT qog hlwb. Tsis tas li ntawd, cov cim kev kuaj mob ntxov tshiab (kev hloov pauv ntawm tus tsav tsheb thiab kev koom tes hauv appendage) thiab cov cim qhia txog kab mob lig (APOE thiab CD163) tau txheeb xyuas thiab siv tau, muab cov ntaub ntawv tseem ceeb rau kev kuaj mob ntxov thiab kev kho mob ntawm acral melanoma.

Yog tias koj xav paub ntxiv txog qhov kev kawm no, nkag musqhov txuas no.Yog xav paub ntxiv txog peb cov kev pabcuam sequencing thiab bioinformatics, koj tuaj yeem tham nrog peb ntawm no.