ʻO keʻano holoʻokoʻa holoʻokoʻa
Ke nānā aku neiʻo Genoms i ka mālamaʻana o Sars-COV-2 iʻole e wehe i kahi hoʻololi o NSP1 e hoʻololi i keʻano o ka paneʻana
Nanoha | ʻO'Ilurna | ʻO Genome Recent | huihi RNA-SOOK | Thane
Hāʻawiʻia nāʻenehana biomarker i ke kākoʻoʻenehana ma keʻano he selenecking selenecing i kēia aʻo.
Nā Hōʻailona
1.Sars-cov-2 genome seequence a me phylognetic requyis e hōʻike i nā 35 recurrent a me nā mea hana hou a me 4 mau pahu.
2.Asosococococococococociation me 117 Clinical Phenotypes e hōʻike ana i ka hiki
nā mana koʻikoʻi.
Δ500-532 ma NSP1 COWD CORDE BORTER BORTER TROTO me ka viral haʻahaʻa
3.load a me serum ifn-β.
4.Viral isouble me Δ500-532 mutation e hoʻopili i lalo o ka haʻahaʻa inā i
pane i nā cell i hoʻopiliʻia.
Hoʻolālā hoʻokolohua
LoaʻaʻO ka Loaʻa
1
Ua hōʻiliʻiliʻia nāʻikepili Clinical ma SICHOUN, Kina ma kahi o ka manawa waho mai Jan. 2020. He 2020. He 2020.ʻO 2020.ʻO 2020.ʻO 2020.ʻO ka 2020. kapikala. Ua hōʻoiaʻia nā hihia i loko o Sichuan i hoʻonuiʻia, e hele ana ma Jan. 30th. Eia kekahi, kākoʻoʻia nā data e hiki i ka weheʻana keʻano o kaʻikeʻana i keʻano nui i ka paleʻana i ka paila.
Kiʻi 1. EpidemOlogical aʻo o Covid-19 ma SICACOUN SOCINCE, Kina
2. Sars-cev-2 genome kūkulu kūkulu a me nāʻano likeʻole
Me ka heihei pcr pcrfpex 80% o nā genomes i uhiʻia e 10 heluhelu i nā mea heluhelu
Kiʻi 2.ʻO ka pinepine o kēlā me kēiaʻano likeʻole i ka coachtan cohort
ʻO ka huina o 104 GRPS a me 18 mau mea iʻikeʻia mai nā sars-cev-2 genomes, i hōʻikeʻia a me 4 mau kāleka i nāʻano likeʻole. Ma ka hoʻohālikelikeʻana iā lākou me 169 mau hiʻohiʻona mai Wauhan a me 81,391 kiʻekiʻe i hōʻikeʻia ma Gisaid i hōʻikeʻia i nā'āina'ē aʻe. ʻAʻole loa,ʻehā mauʻano likeʻole Δ500-532, acc18107 a hele mai i kahi o nā hōʻailona gisuan mai Wauhan, e hālāwai ana me ka nā moʻolelo huakaʻi o nā maʻi maʻi.
ʻO ka hoʻohālikelikeʻana o ka hoʻohālikelikeʻana me ka nui o ka like o keʻano (ml) ʻO Genoms me Δ500-532 Ua hōʻikeʻo Haplotype i nāʻano NSP1 i hōʻikeʻia 5 o lākou mai nā kūlanakauhale he nui. Ua hōʻike kēia mau hopena i ka Δ500-532 i hele i nā kūlanakauhale he nui a iʻole e laweʻia i nā manawa he nui mai Wauhan.
Kiʻi 2.ʻO nāʻano genetic genetic genetic and phylogenetic i ka loiloi o ka sers-2 genmes
3
117ʻO Phenonical Phenotypes i pili me keʻano o Covid-19 Severtity, kahi o 19 Suetity Phenotypes i hoʻopaʻaʻia i loko o nāʻano koʻikoʻi a me nāʻano likeʻole. ʻO ka pilina ma waena o kēia mau hiʻohiʻona a me 35 mau mea hana genetic genetic valiant Ua hōʻikeʻia kahi loiloi inoa inoa inoaʻo GSASA-like me Δ500-532. Eia kekahi, hōʻikeʻia nā hōʻike QPCR i hōʻikeʻia e nā maʻi maʻi maʻi me ka virus pohō o Δ500-532 i loaʻa ka nui o ka ct.
Kiʻi 3.ʻO nā hui o 35 mau makahiki genetic genetic genetic me nā phenowpypes clinical
4.ʻO ka hōʻoia ma ka mika e pili ana i nā maʻi lapaʻau e pili ana
I mea e hoʻomaopopo ai i ka pili o Δ500-532 ma NPSH1 mau hana,ʻo Hek239t nā hana piha me nā hōʻai'ē. Ua hoʻopiliʻia nā mea kākau kākau inoa o nā mea i hanaʻia no kēlā me kēia hek239t ʻO nā genes i hoʻokaʻawale nuiʻia i loko o nā mutants i hoʻopili nuiʻia i ka "peptide bioysnthetic / metabolicrot", etc.
Kiʻi 4.ʻO ka nānāʻana i ka nānāʻana ma nā papa hek239t
ʻO ka piliʻana o nā deletions ma Ifn-1 pane i hōʻikeʻia i ka hoʻopaʻaʻana i ka hoʻopaʻaʻana ma mua. Ua hōʻikeʻia nā mea hōʻike a pau i hōʻikeʻia e hōʻemi ai i ka resos-1 resosse i ka hek239t a me nā'ōnaehana crall ce translacptomeʻelua. Hoihoi, ua hoʻonuiʻia nā gene i lalo o nā deletions i nā deletions "i ka paneʻana i ka maʻi"
Kiʻi 5. I lalo o ka hoʻoponoponoʻana o nā ala hōʻailona inoa interferon ma Δ500-532 MUAT
Ma kēia noiʻiʻana, ka hopena o kēia mau kālepa i ponoʻia ma ka virus i hōʻoiaʻia e nā haʻawina maʻiʻoi aku. ʻO nā maʻi me kekahi mau mika i hoʻokaʻawaleʻia mai nā slinic clinical a iʻole i hoʻopiliʻia i nā callu-3 mau cell. Hiki ke heluheluʻia nā hopena kiko'ī ma ke aʻoʻana i ke aʻoʻana ma ka pepa.
ʻO Doi:10.1016 / J.chom.2021.01.01.015
Kamaʻilio
Lin J B, Tang c, wei h, et al. Ke nānā neiʻo GenomIc i ka mālamaʻana o Sars-COV-2 iʻole e wehe i kahi hoʻololi np1 ʻO ka mea kaua a me ka Microbe, 2021.
Nūhou a me nā Mea Hanohano nā Aims e kaʻana like i nā hihia kūleʻa hou me nāʻenehana biomarker hou, hopu i nā hanaʻepekema maikaʻi loa e pili ana i ka hanaʻana i nāʻano hana.
Hōʻike manawa: Jan-06-2022