Hoʻolaha ʻia

Nuhou hauʻoli! Ua hoʻomohala ʻo BMKGENE i ka BMKMANU S series spatial transcriptomic chip me ka ʻenehana segmentation cell i kōkua ʻia e ka loiloi kiʻekiʻe kiʻekiʻe o ka clonal evolution pattern o acral melanoma e ka hui o Li Hang, Zhang Ning, a me Xue Ruidong mai ke Kulanui ʻo Peking, ua paʻi ʻia ka noiʻi ma. Kelepona maʻi maʻi (IF=50.3).

ʻO ke aʻo ʻana, e pili ana i ka sequencing multi-omics me ka whole-exome, microdissected multi-regional whole-exome, bulk transcriptome, single-cell transcriptome, spatial transcriptome, a me CODEX spatial proteomics, ua hōʻike ʻia i ka ʻōnaehana clonal evolution o ka mua acral melanoma a hoʻokumu ʻia. kona mau subtype mole. Ma ka hoʻohana ʻana i ka BMKMANU S1000 spatial transcriptome cell segmentation technology, 10 acral melanoma poʻe maʻi i nānā ʻia, e hōʻoiaʻiʻo ana i nā pilina spatial pololei ma waena o APOE +/CD163+ TAMs a me nā pūnaewele EMT. Eia kekahi, ua ʻike ʻia a hōʻoia ʻia nā hōʻailona diagnostics mua (nā hoʻololi o ke kaʻa a me ka hoʻopili ʻana) a me nā hōʻailona prognosis hope (APOE a me CD163), e hāʻawi ana i ka ʻike koʻikoʻi no ka hoʻomaʻamaʻa mua ʻana a me ka mālama pololei ʻana i ka melanoma acral.

Inā makemake ʻoe e aʻo hou e pili ana i kēia haʻawina, e komokeia loulou.No ka ʻike hou aku e pili ana i kā mākou sequencing a me nā lawelawe bioinformatics, hiki iā ʻoe ke kamaʻilio me mākou ma aneʻi.