BMKGENE ya ba da jerin ayyukan RNA mai yawa da sabis na bincike don wannan binciken: Rauni masu kutsawa adipocytes ba su ne myofibroblasts ba.
An buga labarin a cikin Nature Communications, yana bincika yuwuwar filastik adipocytes da fibroblasts bayan rauni na fata. Yin amfani da bin diddigin jinsin halittu da kuma raye-raye a cikin raye-raye da kuma a cikin dabbobin da suka ji rauni, lura cewa rauni yana haifar da yanayin ƙaura na wucin gadi a cikin adipocytes tare da ƙayyadaddun yanayin ƙaura cell da halaye daga fibroblasts.
Bugu da ƙari, adipocytes masu ƙaura, ba sa taimakawa ga samuwar tabo kuma suna zama marasa fibrogenic a cikin vitro, a cikin vivo, da kuma lokacin dasawa zuwa raunuka a cikin dabbobi. A taƙaice, adipocytes na ƙaura da ke haifar da rauni sun kasance cikin ƙuntatawa na zuriya kuma ba sa haɗuwa ko sake tsara su cikin nau'in fibrosing phenotype. Wadannan binciken sun yi tasiri sosai akan dabarun asali da na fassara a cikin filin magani na farfadowa, ciki har da ayyukan asibiti don gyaran raunuka, ciwon sukari, da cututtukan fibrotic.
Danna nan donƙarin koyo game da wannan binciken
Lokacin aikawa: Agusta-29-2023